Supervisor
Dr. Lila Allou
Lila Allou established her research group at the MRC LMS in 2024. She is a molecular geneticist whose research focuses on understanding how structural variants (SVs) in the non-coding genome contribute to human development and disease. Her group combines human and mouse models with genome-editing and other genomic approaches to determine how changes in chromosome structure and regulatory DNA alter gene function.
Selected publications
Ringel A.R. et al. | Temporal loss of En1 during limb development causes distinct phenotypes.
Genes Dev. (2026), DOI: 10.1101/gad.353542.125
Allou L. & Mundlos S. | Disruption of regulatory domains and novel transcripts as disease-causing mechanisms.
BioEssays (2023), DOI: 10.1002/bies.202300010
Allou L. et al. | Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator.
Nature (2021), DOI: 10.1038/s41586-021-03208-9
Allou L. et al. | 14q12 and severe Rett-like phenotypes: new clinical insights and physical mapping of FOXG1-regulatory elements.
Eur. J. Hum. Genet. (2012), DOI: 10.1038/ejhg.2012.127
Research group website: https://lms.mrc.ac.uk/research/genomic-variation-and-disease/