Supervisor
Dr. Raffaele Teperino
Dr. Raffaele Teperino has led the Environmental Epigenetics Research Group at the Institute of Experimental Genetics, Helmholtz Munich, since 2015. His research investigates how parental environment and metabolic health reshape germ-cell and non-germ-cell signals at conception and program offspring physiology, with expertise in sperm RNAs, mitochondrial biology, early-embryo metabolism, epigenomics and mouse metabolic phenotyping. His group combines mechanistic animal studies with human cohorts and multi-omics approaches to identify pathways linking pre-conceptional exposures to disease risk.
Selected publications
Tomar A. et al. | Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs. Nature (2024), DOI: 10.1038/s41586-024-07472-3
Trigg N.A. et al. | Ambient temperature shapes the sperm epigenome and influences offspring phenotype. Proc. Natl. Acad. Sci. U.S.A. (2024), DOI: 10.1073/pnas.2409790121
Lassi M. et al. | Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors. Sci. Adv. (2021), DOI: 10.1126/sciadv.abg6424
Darr J. et al. | iTAG-RNA isolates cell-specific transcriptional responses to environmental stimuli and identifies an RNA-based endocrine axis. Cell Rep. (2020), DOI: 10.1016/j.celrep.2020.107621
Research group website: Environmental Epigenetics Research Group